Giant cutaneous squamous cell carcinoma requiring emergent embolization

CT: computed tomography cSCC: cutaneous squamous cell carcinoma NMSC: nonmelanoma skin cancer INTRODUCTION Cutaneous squamous cell carcinoma (cSCC), a subset of nonmelanoma skin cancer (NMSC), is a common form of skin malignancy. National cancer registries have traditionally not tracked cSCC, but its 2012 incidence within the US white population was estimated to be within 186,157 and 419,543. NMSCs greater than 5 cm in size are labeled as giant NMSC. These giant NMSCs usually arise owing to long-term neglect of a slow-growing lesion and pose significant challenges in treatment. Here, we present a case of a giant cSCC in a 70-year-old woman that is unique in several aspects, including its emergent presentation and clinical features that made the cSCC standard treatment impossible. We also describe the clinical course of a novel treatment for cSCC: embolization of the blood supply.